Marrow Transplantation with SCID After Nonablative Allogeneic T Cell Repertoire Development in Humans

نویسندگان

  • Rebecca H. Buckley
  • Daniel A. Ozaki
  • Shui Cao
  • Scott Langdon
  • Marcella Sarzotti
  • Dhavalkumar D. Patel
  • Xiaojing Li
  • Roberta E. Parrott
  • Katherine Coyne
چکیده

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Competition within the early B-cell compartment conditions B-cell reconstitution after hematopoietic stem cell transplantation in nonirradiated recipients.

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CDR3 spectratyping was used to analyze the complexity of the T-cell repertoire and to define the mechanisms and kinetics of the reconstitution of T-cell immunity after allogeneic bone marrow transplantation (BMT). This method, which is based on polymerase chain reaction amplification of all CDR3 regions using the T-cell receptor (TCR) Vbeta genes, was used to examine serial samples of periphera...

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In allogeneic hematopoietic stem cell transplant recipients, restoration of humoral immunity is delayed and can remain impaired for years. In many severe combined immune deficiency (SCID) patients given haploidentical bone marrow (BM), lesions in humoral immunity are exacerbated by poor engraftment of donor B cells. The nature of these defects is important to understand as they render patients ...

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After allogeneic hematopoietic stem cell transplantation (HSCT), recovery of humoral immunity is essential to protect from life-threatening infections. However, monitoring the humoral immune system after transplantation with standard techniques in the clinical routine is imprecise. Here, we performed sequencing of mononuclear bone marrow cells to characterize the VH1-repertoire of switched B ce...

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تاریخ انتشار 2003